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Design and Synthesis of Multimodal Lanthanide‐based Nanoparticles for Bioapplications Damasco, Jossana Prasad, Paras Chemistry nanoscience nanotechnology materials science Nanotechnology has allowed the fabrication of multifunctional nanoplatforms by integrating various components into a single nanoformulation. Their size compatibility with the biological systems and the development of efficient and flexible approaches that afford control to tailor the physical and chemical properties of these nanostructures with the ability to thoroughly characterize them facilitated a rapid rise in the use of nanoparticles as unique tools for many biological applications. In the clinic, these engineered nanoparticles, capable of diverse functionalities, hold great promise to a more individualized approach to management and therapies of various diseases. Combining contrasts for different imaging modalities in a single agent can give more accurate and detailed information on the physiological and anatomical characteristics of the disease pathology. Integration of imaging into the delivery of therapeutic agents offers a safer and more effective approach by ensuring sufficient accumulation in target tissues and by monitoring the effects both on the target and the surrounding healthy tissues. 2018-06-28T20:34:14Z 2018-06-28T20:34:14Z 2018-06-28T20:34:14Z 2018 Text Dissertation http://hdl.handle.net/10477/78108 eng Copyright retained by author. Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions. State University of New York at Buffalo