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oai:ubir.buffalo.edu:10477/785992025-09-18T04:53:22Zcom_10477_77914col_10477_78397

Impact of Alpha-Lipoic Acid Ingestion on Glucose Tolerance in Subjects with Pre-Diabetes Chrapowitzky, Lauren Rideout, Todd Exercise and Nutrition Sciences nutrition M.S. Alpha lipoic acid has been long examined for its potential in modulating metabolic responses, particularly as it relates to insulin sensitivity. This study evaluated the effects of supplementation with alpha lipoic acid on glycemic control and lipid profile in pre-diabetic, overweight/obese adults. The study consisted of a free-living, randomized, two-phase, placebo-controlled cross-over study utilizing 12 pre-diabetic and dyslipidemic subjects. Eligible subjects were randomly assigned to either: i) placebo treatment (600 mg cellulose/day) or ii) alpha lipoic acid treatment (600 mg/day). Compared with the placebo phase, alpha lipoic acid-supplemented subjects demonstrated decreases in serum insulin (p=0.04) and HOMA-IR (p=0.07). However, no change (p>0.05) in serum glucose or lipids (including total cholesterol, LDL-C, HDL-C, triglycerides, non-HDL-C, VLDL-C, LDL/HDL, and TC/HDL) were observed. These study results suggest that supplementation with alpha lipoic acid is a useful strategy to improve insulin sensitivity in pre-diabetic subjects but is not effective in modulating serum lipid level 2018-10-26T02:56:22Z 2018-10-26T02:56:22Z 2018 2018-08-09 17:39:52 Text Thesis http://hdl.handle.net/10477/78599 eng Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions. Copyright retained by author. application/pdf State University of New York at Buffalo