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oai:ubir.buffalo.edu:10477/799352025-09-17T22:00:45Zcom_10477_77914col_10477_79804

Investigating the Phenotype of Amylin Receptor-Expressing Cells in the Ventral Tegmental Area Xie, Yibo; 0000-0002-6401-3383 Mietlicki-Baase, Elizabeth Exercise and Nutrition Sciences nutrition neurosciences public health M.S. The role of amylin in regulating energy balance through its ability to suppress food intake by increasing satiation makes it a promising therapeutic method for obesity. Calcitonin receptor (CTR) is the core component of the amylin receptor and activation of the amylin receptor in the ventral tegmental area (VTA), which is located in the dopamine reward pathway, reduces food intake. This study is designed to investigate the VTA cell types that express amylin receptors and the influence of sex and diet differences on VTA amylin receptor colocalization in male and female rats were maintained on chow or a palatable high-fat diet. Immunohistochemical analyses showed VTA CTR is highly co-localized with dopamine neruons and neuronal cells regardless of sex and diet (chow or high fat diet), but is not colocalized with astrocytes. Collectively, these results indicated that the phenotype of VTA cells expressing the amylin receptor is highly dopaminergic and neuronal. 2019-07-30T15:11:14Z 2019-07-30T15:11:14Z 2019 2019-05-14 00:00:31 Text Thesis http://hdl.handle.net/10477/79935 eng Users of works found in University at Buffalo Institutional Repository (UBIR) are responsible for identifying and contacting the copyright owner for permission to reuse. University at Buffalo Libraries do not manage rights for copyright-protected works and cannot assist with permissions. Copyright retained by author. application/pdf State University of New York at Buffalo