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Photoactivated 1,3-dipolar cycloaddition as a new bioorthogonal reaction
A mild, photoactivated 1,3-dipolar cycloaddition procedure based on photolysis of 2,5-disubstituted tetrazoles was successfully developed to serve as a new bioorthogonal reaction called photoclick chemistry. This procedure ...
Part I. The use of small-molecule substrates as probes of the ubiquitination pathway Part II. Intramolecular 1,3-dipolar cycloaddition reaction for peptide 'stapling'
Posttranslational modifications are modifications which occur after a polypeptide or protein has been translated and are used for cell signaling, protein trafficking, localization and degradation among many other pathways. ...