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The role of ubiquitin in erythroid terminal differentiation
Ubiquitin is a major protein that has been highly conserved in all eukaryotic organisms and is involved in various cellular processes such as metabolic homeostasis, organelle biosynthesis, cell cycle regulation, DNA repair, ...
The role of RIP ubiquitination in the TNFalpha signaling pathway
Stimulation of cells by TNFα triggers recruitment of various signaling molecules, including RIP, to the TNFα receptor 1 complex, which leads to activation of NF-κB. Previous studies indicate that RIP plays an essential ...
Molecular mechanism of inhibitor of kappa B kinase (IKK) complex activation by inducible phosphorylation and ubiquitination upon T cell receptor (TCR) stimulation
IκB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ/NEMO. The activation of IKK complex ...