Now showing items 1-5 of 5
Understanding the structure of eukaryotic glutaminyl-TRNA synthetase: Combining X-ray crystallography with statistical evaluations of small angle scattering data
Proteins are the machinery of the cell, carrying out critical functions in living organisms. Amino acyl tRNA synthetases perform the vital cellular function of attaching amino acids to their cognate tRNA molecule for their ...
Structural characterization of JAA-F11-Fab by X-ray crystallography
Thomsen Friedenreich antigen (TF-Ag), is a carbohydrate antigen found on many types of tumors, including breast, prostate, bladder and ovarian. Passive transfer of JAA-F11, a monoclonal anti-TF-Ag antibody, has been shown ...
A computational study of crystallization data: Application and potential prediction
Protein crystallization is an ongoing bottleneck in the process of protein structure determination via X-ray crystallography. The advent of large structural biology projects such as the Protein Structure Initiative (PSI) ...
Structural elucidation of cyclooxygenase enzymes provides insight into the specific stereochemistry of the cyclooxygenase reaction mechanism along with the formation of 15R cyclooxygenase products
Cyclooxygenase (COX) enzymes are heme containing enzymes that catalyze the conversion of Arachidonic (AA) to prostaglandin H 2 (PGH 2 ) during the committed step in prostanoid biosynthesis. This consists of two sequential ...
Structural, functional, and computational insights into the ANL superfamily of enzymes
Members of the ANL superfamily of enzymes are involved in primary and secondary metabolism throughout all domains of life and identify key pathways that contribute to essential physiological reactions as well as defense ...