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Both FLT3-ITd and NPM1 mutations are associated with decreased MLLT3 mRNA expression in acute myeloid leukemia
BACKGROUND: Acute myeloid leukemia (AML) is a molecularly heterogeneous disease characterized by the accumulation of acquired somatic genetic alterations. The most clinically relevant gene mutations include internal tandem ...
Non-coding rnas in the pathogenesis of core-binding factor acute myeloid leukemia
Core-binding factor acute myeloid leukemia (CBF-AML) is a subgroup of acute myeloid leukemia (AML), classically defined by the presence of non-random chromosomal rearrangements involving the core-binding factor (CBF), a ...