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Phosphatidylserine mediated enhancement of the therapeutic efficacy of B domain deleted recombinant factor VIII
Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade. Deficiency or dysfunction of FVIII causes hemophilia A, a life threatening bleeding disorder. Replacement therapy using FVIII is the first line ...
Immunogenicity of recombinant human factor VIII: Influence of protein aggregation and excipients
Factor VIII (FVIII) is a multi-domain plasma glycoprotein comprised of A1-A2-B-A3-C1-C2 domains and is an essential cofactor in the coagulation cascade. Its deficiency or dysfunction causes hemophilia A, a debilitating ...