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Thermal sensitivity of lipid raft composition regulates lymphocyte activation threshold: Characterizing molecular and functional effects of mild thermal stress on the lymphocyte plasma membrane
Because of their particular composition, “lipid rafts” found within the plasma membrane of T lymphocytes selectively associate with certain membrane proteins and as such, play a critical role in activation and signaling. ...
Mild hyperthermia influences macromolecular dynamics at the T cell surface thus increasing the efficiency of stimulatory signals
There is growing recognition of the fact that although the effects of fever-range hyperthermia may be less extreme than that of heat shock temperatures, they may be more biologically significant. Our lab recently demonstrated ...
The interplay of signaling pathways and Ets factors in B cell differentiation
Ets1 is a transcription factor that is highly expressed in B cells and T cells. Ets1 is important in regulating B cell differentiation to antibody secreting plasma cells, and Ets1 deficient mice develop lupus-like autoimmune ...
Interleukin-17 gene regulation in T cells
IL-17 is the founding member of a novel family of cytokines and plays a central role in inflammation, rheumatoid arthritis and lung disease. However, little is known about how IL-17 expression is controlled. This study ...
Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells
The tumor microenvironment of human non-small cell lung cancer (NSCLC) is composed largely of stromal cells, including fibroblasts, yet these cells have been the focus of few studies. Here, we established stromal cell ...