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Mechanism of anionic phospholipids mediated mitigation of immunogenicity of recombinant human factor VIII
The primary objective of this research work was to take a rational and stepwise approach to investigate the mechanism of phosphatidylserine/phosphatidylinositol (PS/PI) effect on reducing Factor VIII immunogenicity. The ...
Role of macromolecular interactions in the pharmacokinetics and immunogenicity of recombinant human factor VIII and factor VIII-lipid complex
The primary goal of this dissertation was to systemically study the role of the macromolecular interactions involved in the pharmacokinetics and immunogenicity of Factor VIII (FVIII). The C2 domain of FVIII (a) provides a ...
Phosphatidylinositol reduces the immunogenicity and clearance of human recombinant factor VIII in hemophilia a mice
Factor VIII (FVIII), an important cofactor in blood coagulation cascade, is a multidomain protein that consists of six domains, NH 2 -A1-A2-B-A3-C1-C2-COOH. The deficiency or dysfunction of FVIII causes hemophilia A, a ...