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Progress toward the total synthesis of the epoxyquinoid family of natural products
Enyne metathesis is a powerful C-C bond forming reaction that combines an alkene and an alkyne and forms a conjugated 1,3-diene. The scope of enyne metathesis was expanded by combining various alkynes with vinyl ethers. ...
Enyne metathesis methods applied toward the total synthesis of natural products
Enyne metathesis is an extremely powerful method for the synthesis of conjugated 1,3-dienes that possess a variety of substitution patterns. This atom-economical transformation allows for complex functionality to be brought ...
Applications of enyne metathesis: Forming new methods and expanding scopes for use in natural product synthesis
Chapter 1. The biologically active epoxyquinoids are found to be inhibitors of cancer in tumor cell lines. In particular, the pentaketide dimer epoxyquinol A 1 , is known to inhibit angiogenesis (new blood vessel formation) ...
I. Lewis acid induced tandem Diels-Alder reaction/rearrangements. II. Total syntheses of natural products using the combined carbon-hydrogen activation/Cope rearrangement as the key step
The first project of this thesis was the Lewis acid mediated tandem Diels-Alder reaction/rearrangements. There are two novel reactions that have been discovered. One is a Lewis acid induced tandem Diels-Alder reaction/ring ...
Enantioselective tandem cyclopropanation/Cope rearrangement of heteroaryldiazoacetates and their applications in natural product synthesis
The first section of this thesis focuses on the use of heteroaryldiazoacetates in the tandem cyclopropanation/Cope rearrangement. This reaction was found to be highly successful with various heteroaryldiazoacetates including ...