Search
Now showing items 1-10 of 10
Mannosylated bio-synthetic hybrids for targeted antigen presenting cell gene delivery
(2015)
The aim of gene delivery research is to develop clinically pertinent vectors that can be used to combat elusive diseases. Moreover, gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and ...
Impairment in the Ubiquitin Proteasome System in hereditary peripheral neuropathies
(2017)
In several neurodegenerative diseases in which misfolded proteins accumulate there is impairment of the ubiquitin proteasome system (UPS). We tested if a similar disruption of proteostasis occurs in hereditary peripheral ...
Design and analysis: Scaling up of bioreactor towards directed differentiation of human embryonic stem cells
(2012)
Embryonic stem cells will be an effective tool as a renewable source in regenerative medicine mainly due to their extensive proliferation and ability to differentiate into various lineages of cells. Widespread use of ...
Tissue engineering for cardiovascular regeneration - Stem cells, Biomaterials, and Animal preclinical model
(2012)
This thesis addresses some approach for tissue engineering in cardiovascular regeneration. Cell source, biomaterials, ex vivo and in vivo assessment are all discussed step by step. This dissertation provides a good ...
Chemical and Biological Attenuation Methods for Bacterial Mediated Gene Delivery
(2014)
The development of nonviral vectors for safe and effective gene delivery system is acquiring significant consideration at the present time. Ideally a nonviral vector must overcome the barrier of extracellular milieu, ...
Matrigel and Mass Spectrometry
(2014)
Matrigel is one of the most prolific 3-D growth cultures used for tumor invasion assays, tissue engineering and for stem cell growth. Produced from the Engelbreth-Holm-Swarm (EHS) tumor sarcoma cells of mice and containing ...
Inter-domain regulation of Von Willebrand factor's function: Platelet adhesion, activation and aggregation in blood
(2013)
Cardiovascular diseases are the primary cause of deaths worldwide and according to the World Health Organization; it is projected to cause the death of about 25 million people by 2030. Multiple factors cause the abnormalities ...
Mathematical Modeling of N-Glycosylation: Model Construction and Parameter Estimation from Mass Spectra of Chinese Hamster Ovary Cell Mutants
(2013)
Colossal advances in molecular cellular biology have witnessed the growth of genomics, proteomics and other "–omics" fields, built on reductionist approaches aimed at annotating a vast array of biological components, from ...
R Packages for density based empirical likelihood based hypothesis tests
(2013)
This thesis presents the functionality of two new R packages for performing goodness-of-fit tests based on density based empirical likelihood methods: dbEmpLikeGOF and dbEmpLikeNorm. The dbEmpLikeGOF function dbEmpLikeGOF ...
Biosynthesis of anthocyanin in metabolically engineered Escherichia coli
(2011)
Anthocyanins are water-soluble colored pigments found in terrestrial plants. They are responsible for the red, blue and purple coloration of many flowers, fruits and other plant parts. Anthocyanins have been known to possess ...