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Tumor vasculature as a therapeutic target for calcitriol in cancer
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
Function and regulation of protein kinase C alpha in the intestinal epithelium
The protein kinase C (PKC) family of serine/threonine kinases participates in regulation of cell proliferation and survival in a variety of systems. PKCα is a ubiquitously expressed member of the PKC family. In the intestinal ...