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Development of Nano-Liposomal Formulations of Epidermal Growth Factor Receptor Inhibitors and their Pharmacological Interactions on Drug-Sensitive and Drug-Resistant Cancer Cell Lines
(2010)
A rapidly expanding understanding of molecular derangements in cancer cell function has led to the development of selective, targeted chemotherapeutic agents. Growth factor signal transduction networks are frequently ...
Anti-inflammatory cytokine IL-10 and mammary gland development
(2010)
Background . IL-10 is an anti-inflammatory cytokine produced by Th2 T helper cells and it has pleiotropic effects in immunoregulation and inflammation. It inhibits the regulation of Th1 T helper cells, MHC class II expression ...
Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
(2010)
Host immune responses, including the characteristic influx of neutrophils, against Neisseria gonorrhoeae are poorly understood; adaptive immunity is minimal and nonprotective. The importance of the newly defined Th17 cell ...
Molecular mechanisms of resveratrol induced cell death in MDA-MB-231 breast cancer cells
(2010)
Metastatic breast cancer is one of the leading causes of cancer related death in women. Surgery in combination with radiation and chemotherapy has shown promising results for breast cancer therapy. However, toxicity and ...
Effects of atrial natriuretic peptide on rat pancreatic islet beta-cells
(2010)
Atrial natriuretic peptide (ANP), a 28-amino acid peptide, is primarily expressed and stored in granules in the atria, and are released during atrial stretch due to volume overload or hypertension in the cardiovascular ...
Degeneration of cochlear SGNs caused by salicylate
(2010)
Aspirin, whose active ingredient is sodium salicylate, has been extensively used as an anti-inflammation medicine. When administered at high doses (≥ 1 mM CSF), salicylate reliably induces temporary hearing loss and tinnitus. ...
Acetylcholine receptor-channel gating
(2010)
The probability that muscle type acetylcholine receptors become conductive to ions increases in response to binding of two ligand molecules. The mechanism of this gating reaction is not yet fully understood. A wide range ...
Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are inhibitors of the breast cancer resistance protein (ABCG2) transporter
(2010)
Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PDBEs) are structurally similar persistent organic pollutants (POPs) that elicit a variety of biological and toxicological responses. The Breast Cancer ...
Muscle biomarkers of type 2 diabetes disease progression in Goto-Kakizaki rats
(2010)
Muscle is an important component of systemic glucose homeostasis, and insulin resistance is a common feature of most human type 2 diabetics. This thesis aims at characterizing some aspects of disease progression in type 2 ...
Identification and characterization of an Acinetobacter baumannii biofilm-associated protein
(2010)
Acinetobacter baumannii is a Gram-negative bacterium that has emerged recently as an important nosocomial opportunistic pathogen. In 1975, Acinetobacter species accounted for 1.5 and 1.8% of bacterial isolates associated ...