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Genetically altered expression of polyamine acetylation affects fat metabolism and body fat accumulation in mice
(2007)
The polyamine acetylating enzyme, spermidine/spermine N 1 -acetyltransferase (SSAT), catalyzes the transfer of acetyl groups from acetyl-coenzyme A (acetyl-CoA) onto intracellular polyamines thereby rendering them susceptible ...
Characterizing regions associated with genomic instability in colon cancer
(2007)
Most cancers can be considered to be the consequence of an unstable genome, where the instability can arise exogenously from carcinogens or endogenously from defects in systems that maintain genomic integrity. Genomic ...
Tumor vasculature as a therapeutic target for calcitriol in cancer
(2007)
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
The effect of phytosterols on the cytokine release from monocytes from multiple sclerosis patients
(2008)
Objectives. To assess the immunomodulatory effects of the plant sterol, β-sitosterol, on peripheral blood mononuclear cells of multiple sclerosis (MS) patients and to compare its effects to those of simvastatin. Background. ...
Phosphatidylserine mediated enhancement of the therapeutic efficacy of B domain deleted recombinant factor VIII
(2007)
Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade. Deficiency or dysfunction of FVIII causes hemophilia A, a life threatening bleeding disorder. Replacement therapy using FVIII is the first line ...
The DNA damage induced by, and cellular responses to, the C-1027 family of antitumor antibiotic radiomimetic enediynes
(2007)
My thesis research involves the characterization of a novel pathway that cells activate in response to DNA double strand breaks. The activation of DNA repair and cell cycle checkpoint responses following the induction of ...
A protective effect of exercise against interpersonal stress-induced cardiovascular reactivity in youth
(2007)
Background. Empirical evidence suggests an association between blood pressure reactivity to psychological stress in childhood and hypertension in adulthood. Acute aerobic exercise dampens blood pressure reactivity to ...
Characterization ofhsp110 andgrp170 interactions with scavenger receptors
(2007)
Hsp110 is a cytosolic chaperone protein and grp170 is a related endoplasmic reticulum chaperone protein. Both can induce immune responses against tumors when complexed to tumor antigens and injected into mice. Mechanisms ...
Expression of TrkB at the neuromuscular junction during aging
(2007)
There is increasing evidence that age associated alterations in innervation may underlie many of the changes that occur in skeletal muscle during senescence. Aging of the neuromuscular system is associated with loss of ...
Development and evaluation of a new high-sensitivity, region-of-interest, x-ray imaging system for neuro-interventional applications
(2007)
Neurovascular image-guided interventional (IGI) procedures require very high resolution (3 to 10 lp/mm), large dynamic range, and real-time imaging capability for visualization and navigation of endovascular devices during ...