Now showing items 1-10 of 148
Study of the effect of tungsten shields on the radiation dose delivery in a gynecological applicator using Gafchromic film dosimetry
Fletcher Suit Delclos applicator is employed for high dose rate intracavitary brachytherapy treatment of cervical cancer. It includes tungsten shields in the direction of bladder and rectum to limit their radiation exposure. ...
Molecular mechanisms of conformational specificity: A study of Hox in vivo target DNA binding specificities and the structure of a Ure2p mutation that affects fibril formation rates
The fate of an individual cell, or even an entire organism, is often determined by minute, yet very specific differences in the conformation of a single protein species. Very often, proteins take on alternate folds or even ...
The role of protein methylation in growth of Saccharomyces cerevisiae and a disruption mutant of SAH1
Growth of a disruption mutant of S-adenosylhomocysteine hydrolase (Δ SAH1) in S.cerevisiae is severely defective. A prolonged lag precedes log growth, the rate of log growth is 6.7-fold less than WT, and the number of cells ...
Developing site selectively templated and tagged xerogels as sensor platforms
Biologically-based recognition elements (e.g., antibodies, aptamers, enzymes) are used as the recognition element within a wide variety of assays and sensor systems. There are, however, compelling reasons for researchers ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
The role of DNA replication in mismatch repair
DNA Mismatch Repair (MMR) plays an important role in maintaining genomic fidelity and stability in all living organisms, ranging from bacteria to humans, and is known to be closely associated with DNA replication and present ...
Identification of methylation-dependent biochemical associations of the THO complex
Pre-mRNAs must be fully processed and packaged into mature messenger ribonucleoparticles (mRNPs) before being exported to the cytoplasm as fully translatable mRNAs in eukaryotic cells. The intracellular RNA processing steps ...
Structural elucidation of cyclooxygenase enzymes provides insight into the specific stereochemistry of the cyclooxygenase reaction mechanism along with the formation of 15R cyclooxygenase products
Cyclooxygenase (COX) enzymes are heme containing enzymes that catalyze the conversion of Arachidonic (AA) to prostaglandin H 2 (PGH 2 ) during the committed step in prostanoid biosynthesis. This consists of two sequential ...
Studies of structure, hydration and dynamics of biological macromolecules by use of NMR spectroscopy
Nuclear magnetic resonance (NMR) has emerged as a powerful tool for studying biological macromolecules in aqueous solution. This dissertation describes the efforts to study the structure, hydration and dynamics of biological ...
Vitamin C and collagen IV formation in fibroblasts
Collagen IV (Col4) is a major component of vascular basement membranes (BM). Mice expressing mutated Col4 died shortly after birth with cerebral hemorrhage. Mice lacking the ubiquitous vitamin C (Asc) transporter SVCT2 ...