Now showing items 1-10 of 30
Development of Nano-Liposomal Formulations of Epidermal Growth Factor Receptor Inhibitors and their Pharmacological Interactions on Drug-Sensitive and Drug-Resistant Cancer Cell Lines
A rapidly expanding understanding of molecular derangements in cancer cell function has led to the development of selective, targeted chemotherapeutic agents. Growth factor signal transduction networks are frequently ...
Tumor vasculature as a therapeutic target for calcitriol in cancer
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
Fibroblast modulation of T lymphocyte activation
Fibroblasts are a dominant cell type amongst the mixed population of tumor, stromal, and inflammatory cells found in the microenvironment of most human solid tumors. The possibility that fibroblasts have the capacity to ...
Dendritic cell-based approaches for the immunotherapy of malignant diseases
The overall goal of this thesis is to develop and evaluate the immunogenicity and therapeutic efficacy of several interrelated strategies for the active specific immunotherapy of malignant diseases. The primary focal point ...
Improving the efficacy and selectivity of photodynamic therapy (PDT): Preclinical evaluation of a novel combination strategy for cancer
Clinical application of photodynamic therapy (PDT) is limited by treatment failures that lead to tumor recurrences in patients. Based on previous observations that administration of tumor necrosis factor-alpha (TNF-α) ...
Periodontal disease and cancer: Chronic inflammation - the oral-systemic link
Abstract removed at author's request.
Redirecting cancer kinase signaling: A novel rewiring of Bcr/Abl and PKC Beta II
Mutations in cancer very frequently cause aberrant signal transduction. This dysfunctional signaling blocks apoptotic and differentiation pathways, activates proliferative and survival pathways, and plays a central role ...
Optimization of tumor-imaging and therapeutic potential of near-infrared multifunctional agents, and targeted polyacrylamide theranostic nanoplatforms
The goal of this work was to modify the structural parameters of porphyrin-based agents to optimize their imaging and/or therapeutic potential. In order to achieve our goal, certain chlorins and bacteriochlorins were ...
Effect of defucosylation on humanized JAA-F11 antibody against TF-antigen and comparison of cytotoxicity with fucosylated counterparts
JAA-F11 is a mouse monoclonal antibody specific to Thomsen Friedenreich Antigen, which is a carbohydrate antigen expressed on several types of carcinomas and serves as a novel target for development. Humanization of the ...
The Role of Mitochondria in Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the third most common type of solid tumors in children. The two main subtypes of RMS widely studied are embryonal RMS (eRMS) and alveolar RMS (aRMS). aRMS is characterized to have a more aggressive ...