Now showing items 1-10 of 25
Development of Nano-Liposomal Formulations of Epidermal Growth Factor Receptor Inhibitors and their Pharmacological Interactions on Drug-Sensitive and Drug-Resistant Cancer Cell Lines
A rapidly expanding understanding of molecular derangements in cancer cell function has led to the development of selective, targeted chemotherapeutic agents. Growth factor signal transduction networks are frequently ...
Fibroblast modulation of T lymphocyte activation
Fibroblasts are a dominant cell type amongst the mixed population of tumor, stromal, and inflammatory cells found in the microenvironment of most human solid tumors. The possibility that fibroblasts have the capacity to ...
Regulation of hormone responsive cancers by Ca 2+ /calmodulindependent protein kinase kinase 2
Steroid Receptors (SR) are oncogenic drivers of proliferation in hormonally regulated cancers. Immunohistochemistry (IHC) studies have shown high expression levels of Ca2+/calmodulin-dependent kinase kinase 2 (CaMKK2), an ...
Periodontal disease, the oral microbiome, and their associations with cancer risk in postmenopausal women
Background: Periodontal disease refers to the chronic polymicrobial infection of the oral cavity, and is characterized by gingival inflammation, leading to loss of supporting connective tissue surrounding the teeth and ...
Both FLT3-ITd and NPM1 mutations are associated with decreased MLLT3 mRNA expression in acute myeloid leukemia
BACKGROUND: Acute myeloid leukemia (AML) is a molecularly heterogeneous disease characterized by the accumulation of acquired somatic genetic alterations. The most clinically relevant gene mutations include internal tandem ...
Sleep Quality, Duration and Breast Cancer Tumor Aggressiveness
Background: Epidemiological studies have reported that poor sleep quality and short sleep duration may increase breast cancer risk. However, whether sleep is associated with breast cancer tumor aggressiveness, particularly ...
Periodontal disease and cancer: Chronic inflammation - the oral-systemic link
Abstract removed at author's request.
Molecular mechanisms by which interferon regulatory factor-8 (IRF-8), a member of the IRF family of transcription factors, suppresses tumor progression of both hematopoietic and nonhematopoietic malignancies
It is well recognized that deregulation of certain transcription factors is indispensable during tumor progression. Identification and characterization of these genes are therefore fundamental requirements to inhibit the ...
Comparison of humanized, chimeric, and mouse JAA-F11 anti-Thomsen-Friedenreich Antigen antibodies
The Thomsen-Friedenreich Antigen (TF-Ag), the disaccharide Galβ1-3 GalNAcα, that is present on the surface of more than 90% of carcinomas including breast cancers, is a potential cancer therapeutic target. The pancarcinoma ...
Anti-cancer activity of novel camptothecin analogues that are insensitive to ABCG2
Analogues of camptothecin (CPT) have been used in the clinic for almost two decades. The first analogue to be approved, topotecan (TPT), is now approved for use in patients with advanced ovarian, cervical, or small cell ...