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The role of peroxiredoxin 1 in lung cancer: Tumor development and radiotherapy resistance
Peroxiredoxin 1 (Prx1), a major member of peroxiredoxin family, has been observed in various human cancers including lung cancer and its elevation appears to increase the stress resistance of cancer cells. Most studies ...
Smad3 mediates TGF-beta induced apoptosis through the control of survivin expression in human breast cancer cells
Transforming growth factor-β (TGF-β) pathway initiates signaling by assembling receptor complexes that activate Smad transcription factors. TGF-β plays a key role in cell proliferation, differentiation and apoptosis. The ...
Budding yeast origin recognition complex (ORC) and its roles in global transcriptional repression, genome organization and apoptosis
The Origin Recognition Complex (ORC) is a conserved six-subunit protein complex required for initiation of DNA replication in all eukaryotes, as well as transcriptional silencing at the silent-mating type loci in the budding ...
Characterizing the biological effects of Apo2L/TRAIL on tumor cells in vitro and in vivo
Recently, emphasis in cancer research has been on the development of tumor targeted therapies in order to spare the toxic side effects of chemotherapy. While targeted therapies have certain advantages, they are not exempt ...
Signaling pathways mediating conjugated linoleic acid-induced apoptosis
Conjugated linoleic acid (CLA) is a powerful anticancer agent in a number of tumor model systems. CLA inhibits rat mammary carcinogenesis, in part by inducing apoptosis of preneoplastic and neoplastic mammary epithelium. ...