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Effect of fat on inflammation and insulin resistance in human mononuclear cells and myeloid cell insulin receptor knockout mice
Obesity and diabetes are major risk factors for cardiovascular disease. Both have been shown to be associated with oxidative stress and inflammation. These processes are also involved in the pathogenesis of atherosclerosis. ...
A constrained object approach to systems biology
Research has shown that all the information needed to build a detailed model of a cell, including the properties of all constituent components and their interconnectivity, is still not available. However, cells are subject ...
Development and evaluation of a new high-sensitivity, region-of-interest, x-ray imaging system for neuro-interventional applications
Neurovascular image-guided interventional (IGI) procedures require very high resolution (3 to 10 lp/mm), large dynamic range, and real-time imaging capability for visualization and navigation of endovascular devices during ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Integrated feature subset selection/extraction with applications in bioinformatics
Feature subset selection and extraction algorithms are actively and extensively studied in machine learning literature to reduce the dimensionality of feature space, since high dimensional data sets are generally not ...
Approaches to clustering gene expression time course data
Conventional techniques to cluster gene expression time course data have either ignored the time aspect, by treating time points as independent, or have used parametric models where the model complexity has to be fixed ...
Blood flow measurement from digital angiography
Computational fluid dynamic (CFD) simulations are emerging as a promising tool for diagnosis and treatment planning of vascular diseases such as intracranial aneurysms. In addition to the three-dimensional luminal geometry, ...
Micromachined polymeric scaffold with neuron factor gradient for guided spiral ganglion neuron growth
Over 50 million people suffer from acquired hearing loss due to permanent damage to hair cells currently treatable by only cochlear implants. The damaged hair cell in turn causes the demise of spiral ganglion neuron, ...
Efficient retroviral transduction of human epidermal stem cells using recombinant fibronectin
The epidermis is an attractive target for gene therapy because it is easily accessible and shows great potential as an ectopic site for protein delivery in vivo. Genetically modified epidermal keratinocytes are used to ...
Endothelial cell layer subjected to flow mimicking the apex of an arterial bifurcation
Endothelial cell response to shear stress and shear stress gradients is widely accepted as a mediator of vascular pathology, including intracranial aneurysms. To this point, most in vitro research on endothelial cells ...