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Function and regulation of protein kinase C alpha in the intestinal epithelium
The protein kinase C (PKC) family of serine/threonine kinases participates in regulation of cell proliferation and survival in a variety of systems. PKCα is a ubiquitously expressed member of the PKC family. In the intestinal ...
Keratinocyte as a model system for transcriptional control of epithelial homeostasis and carcinogenic transformation
Keratinocytes are specialized epithelial cells making up most of the stratified squamous epithelia of the mammalian epidermis and oral mucosa. In these epithelial tissues, the keratinocytes are arranged such that the ...
Tumor vasculature as a therapeutic target for calcitriol in cancer
Calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D is known to have anti-tumor activity both in vitro and in vivo in a wide variety of malignant cell types. Calcitriol is not only anti-proliferative ...
Dendritic cell-based approaches for the immunotherapy of malignant diseases
The overall goal of this thesis is to develop and evaluate the immunogenicity and therapeutic efficacy of several interrelated strategies for the active specific immunotherapy of malignant diseases. The primary focal point ...
Improving the efficacy and selectivity of photodynamic therapy (PDT): Preclinical evaluation of a novel combination strategy for cancer
Clinical application of photodynamic therapy (PDT) is limited by treatment failures that lead to tumor recurrences in patients. Based on previous observations that administration of tumor necrosis factor-alpha (TNF-α) ...