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Modeling of dopamine-dependent disorders in a transgenic mouse and therapeutic targeting of dopamine circuits through nicotinic acetylcholine receptors
Schizophrenia and Parkinson's disease (PD) and related neurodevelopmental and neurodegenerative disorders are highly prevalent and extremely debilitating diseases. A common feature of these disorders is an impairment of ...
Engineering the acetylcholine receptor gating conformational change
Acetylcholine receptors (AChRs) are allosteric proteins that respond to acetylcholine (ACh) in the extracellular solution. These membrane proteins alternate spontaneously (`gate') between two global shapes, R and R*. R has ...