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Glycan Signature Changes in Stem Cell Differentiation and Cancer
Glycosyltransferase (glycoT) enzymes mediate the transfer of monosaccharide from nucleotide-sugars to carbohydrate, lipid and protein based acceptors leading to formation of glycans. The regulation of the glycan structures ...
P53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of tandem and interspersed repeats
Inactivation or loss of p53 is associated with increased cell sensitivity to the DNA demethylating agent 5-aza-2'-deoxycytidine (5-aza-dC). To identify the factors that trigger apoptotic response under these conditions, ...