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Application of Click Chemistry Towards The Synthesis of Bifunctional Stapled Peptides
Cocktail therapies in cancer treatment are proven to be effective. Compared with cocktail therapies, fused bifunctional peptides are more predictable for their pharmacokinetic properties and potentially synergistic. Here, ...
Alpha-Lipoic Acid Protects Against Weight Gain and Modulates Hepatic Lipid Response to High Fat Feeding in Obese Zucker Rats
Alpha-lipoic acid (R+ isomer, LA) has recently been shown to have anti-obesity and lipid-lowering properties; however, the underlying molecular mechanisms have not been fully elucidated. Our objectives were to examine the ...
Tumor imaging and photodynamic therapy (PDT) using versatile chlorin near infrared fluorophore (NIRF) conjugates
Near-infrared (NIR) organic dyes have become important for many biomedical applications, including in vivo optical imaging. Conjugation of NIR fluorescent dyes to photosensitizing molecules (photosensitizers) holds strong ...
Toward Understanding Ovarian Tumor Metabolism Using NMR-Based Metabonomics Data
Metabonomics can be considered as an advanced methodology to proficiently obtain information from experimental profiles acquired for biofluids. Metabonomics studies use statistical analysis to diagnose diseases, monitor ...
Techniques for the Enhancement of Optimization Schemes in Radiation Therapy
With the advent of intensity modulated radiation therapy (IMRT), the process of generating a radiotherapy treatment plan has become a complex and time consuming process due to an increase in the number of variables which ...
Answering burning questions: Analysis and quantification of halogenated flame retardants and their metabolites in environmental and biological matrices
Polybrominated diphenyl ethers (PBDEs) are used as additive flame retardants in a number of polymers and resins found in consumer products. PBDEs have become classified as persistent organic pollutants (POPs) due to ...