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Cytotoxic T lymphocyte - tumor cell interaction: Monitoring HLA class I antigen and HLA class I antigen - tumor antigen derived peptide complex expression by malignant cells
Poor clinical response rates have been observed in the majority of the T cell-based immunotherapy clinical trials conducted to date. These disappointing results are likely to be caused, at least in part, by tumor cells' ...
Tumor immune escape: Molecular mechanisms and counteracting strategies
Changes in HLA class I antigen and NK cell-activating ligand expression have been identified in malignant lesions. These changes are believed to play a major role in the clinical course of the disease since both HLA class ...
Defining mechanisms by which fever-range thermal stress regulates natural killer cell mediated recognition and killing of tumor cells
All circulating cells, including Natural Killer (NK) cells, normally experience temperature gradients as they move through compartments in the body; however inflammation-driven febrile conditions can expose them to elevated ...