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Embryonic stem cell self-renewal and differentiation in a scalable bioprocess
The goal of this research was to produce a scalable bioprocess for the proliferation and differentiation of embryonic stem cell. Experiments on mouse and human embryonic stem cells grown on traditional culture surfaces, ...
Expansion and directed differentiation of human pluripotent stem cells to insulin-producing cells in a stirred-suspension microcarrier system
Human embryonic stem cells (hESCs) are a promising source of therapeutics for diabetes patients. Of major importance for hESC-based therapies to become a clinical reality is the development of robust, directed differentiation ...
Design and analysis: Scaling up of bioreactor towards directed differentiation of human embryonic stem cells
Embryonic stem cells will be an effective tool as a renewable source in regenerative medicine mainly due to their extensive proliferation and ability to differentiate into various lineages of cells. Widespread use of ...
Directing Mesenchymal Stem Cell Fate toward Smooth Muscle Lineage
Mesenchymal stem cells have tremendous therapeutic potential in regenerative medicine and show excellent safety record in clinical applications. MSCs can differentiate into osteogenic, adipogenic, chondrogenic, and myogenic ...