Now showing items 1-10 of 45
Vitamin C and collagen IV formation in fibroblasts
Collagen IV (Col4) is a major component of vascular basement membranes (BM). Mice expressing mutated Col4 died shortly after birth with cerebral hemorrhage. Mice lacking the ubiquitous vitamin C (Asc) transporter SVCT2 ...
Molecular mechanisms regulating DeltaNp63 expression and function during development and differentiation of mouse skin keratinocytes
The skin is a multilayered stratified epithelium providing a protective barrier against dehydration and pathogenic insult. The transcription factor p63 plays an important role in the development of stratified epithelium ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Applications of the 1,3-dipolar cycloaddition reaction towards the target guided synthesis of small molecule inhibitors and towards peptide stapling
Based on the structure of the known MDM2 inhibitor Nutlin, a series of pyrazoline and pyrazole compounds were synthesized and tested in an ELISA test format, from which 1,5-Bis-( 4-chloro-phenyl)-3-(2-isopropoxy-4-methox ...
X-ray region of interest imaging system for rapid-sequence angiography and fluoroscopy: The micro-angiographic fluoroscope
Neuro-endovascular interventional diagnosis and treatment require high resolution x-ray imaging guidance of fluoroscopy and angiography. Our group has developed a small field of view, 5 frames per second, high-resolution ...
Evaluation of flow with dynamic x-ray imaging for aneurysms
The main goal of this thesis is to evaluate blood flow inside cerebrovascular aneurysms using dynamic x-ray imaging. X-ray contrast substance (dye) was auto injected in elastomer aneurysm models placed in a flow loop (for ...
Analysis of protein-protein and protein-RNA interactions by severe acute respiratory syndrome nonstructural proteins and human karyopherin alpha 2
The severe acute respiratory syndrome (SARS) pandemic that began in late 2003 is a recent example of zoonotic transmission of a novel virus into human populations. The outbreak has highlighted the potential of coronaviruses ...
Metabolic engineering of Escherichia coli and Saccharomyces cerevisiae to mutasynthesize natural phenylpropanoids and novel analogs
The current dissertation investigated the biosynthesis of natural and unnatural flavonoids using Escherichia coli and Saccharomyces cerevisiae. Flavonoids are a diverse group of secondary metabolites found ubiquitously in ...
Environmental and binding dependence of protein terahertz dielectric response
Terahertz (THz) generation and detection techniques have been developed widely and improved in the last few decades. THz techniques have been applied to many fields, such as medical support (THz imaging for breast cancer ...
The response of proteasome activator 200kD to DNA damage
Upon exposure to DNA damaging agents, eukaryotic cells employ a complex cellular response, which includes cell signaling and protein recruitment events, in order to sense and repair DNA damage. The correction of DNA ...