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Smad3 mediates TGF-beta induced apoptosis through the control of survivin expression in human breast cancer cells
Transforming growth factor-β (TGF-β) pathway initiates signaling by assembling receptor complexes that activate Smad transcription factors. TGF-β plays a key role in cell proliferation, differentiation and apoptosis. The ...
Budding yeast origin recognition complex (ORC) and its roles in global transcriptional repression, genome organization and apoptosis
The Origin Recognition Complex (ORC) is a conserved six-subunit protein complex required for initiation of DNA replication in all eukaryotes, as well as transcriptional silencing at the silent-mating type loci in the budding ...