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Anti-cancer activity of novel camptothecin analogues that are insensitive to ABCG2
Analogues of camptothecin (CPT) have been used in the clinic for almost two decades. The first analogue to be approved, topotecan (TPT), is now approved for use in patients with advanced ovarian, cervical, or small cell ...
Identifying and Overcoming Mechanisms of Impaired Myogenic Differentiation in Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and adolescents, and is thought to represent abortive myogenic differentiation due to histology and expression of skeletal muscle-specific factors. ...