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Resolving genome-wide views of chromatin structure to identify fundamental principles of genome organization
Chromatin, the collection of DNA and proteins found in eukaryotic nuclei, is organized into a distinct structure to facilitate the compaction of genomic DNA. Chromatin structure is highly conserved across eukaryotic species ...
Computational tools for investigating the role of chromatin in regulating genomic functional elements
Chromatin is the nucleoprotein complex composed of histone protein and DNA found in the nucleus of every eukaryotic cell. The basic subunit of chromatin is the nucleosome, consisting of 147bp of DNA wrapped around a histone ...