Search
Now showing items 1-10 of 18
Acetylcholine receptor-channel gating
(2010)
The probability that muscle type acetylcholine receptors become conductive to ions increases in response to binding of two ligand molecules. The mechanism of this gating reaction is not yet fully understood. A wide range ...
Assessing PDT response with diffuse optical spectroscopies
(2015)
Photodynamic therapy (PDT) is used to treat a variety of conditions including cancer. Effective PDT requires three components: a photosensitizer (PS), light of a specific wavelength to activate the PS and oxygen. When all ...
Efficient novel nonparametric tests and estimations with applications to biomedical studies
(2012)
Likelihood is arguably the most important concept for statistical inference in parameter models. The Neyman-Pearson lemma states that the likelihood ratio test is the most powerful test when the likelihood functions are ...
Investigating functions of the transcription factor Ets1 in squamous cell carcinoma
(2012)
The skin epidermis comprised of multilayered keratinocytes provides a protective barrier against mechanical and chemical insults, dehydration and other foreign substances. To establish the barrier function of the skin, ...
Methodologies for emerging contaminants in environmental and food matrices by liquid chromatography-tandem mass spectrometry and by capillary electrophoresis-inductively coupled plamsa-mass spectrometry
(2011)
In the first part of this work, simultaneous extraction of estrone (E1), 17β-estradiol (E2), estriol (E3), ethinylestradiol (EE2), and their glucuronated and sulfated metabolites in milk was optimized using solid-phase ...
Development of Novel Ionstar-Based Methods for Large-Scale Tissue and Plasma Proteomics with High Sensitivity and Reproducibility
(2017)
Quantitative proteomics concomitantly analyze numerous proteins in biological samples and thus allows the depiction of a global picture of a dynamically changing proteome, which is inaccessible to conventional reductionist ...
Identifying and Overcoming Mechanisms of Impaired Myogenic Differentiation in Alveolar Rhabdomyosarcoma
(2017)
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and adolescents, and is thought to represent abortive myogenic differentiation due to histology and expression of skeletal muscle-specific factors. ...
Methodology for NMR-based metabonomics and application for detection of early stage epithelial ovarian cancer
(2011)
NMR-based metabonomics can be viewed as an approach to efficiently extract information from a large number of NMR spectra for biofluids using statistical analysis to diagnose diseases and to gain insights on the changes ...
Potential Role of the GLUT4 Tether TUG in AMPK-mediated Glucose Uptake
(2012)
Type 2 diabetes is quickly growing into an epidemic. Often known for its hyperglycemic state, type 2 diabetes also leads to dyslipidemia, β-cell dysfunction, and increased inflammation. These characteristics make the ...
Oxysterol analysis in neurodegenerative diseases and traumatic brain injury
(2014)
Background: There is increasing evidence that an adverse cholesterol profile is associated with neurodegenerative diseases and CNS injury. Oxysterols are oxygenated metabolites of Cholesterol that may provide the link ...