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Anti-cancer activity of novel camptothecin analogues that are insensitive to ABCG2
Analogues of camptothecin (CPT) have been used in the clinic for almost two decades. The first analogue to be approved, topotecan (TPT), is now approved for use in patients with advanced ovarian, cervical, or small cell ...
Optimization of tumor-imaging and therapeutic potential of near-infrared multifunctional agents, and targeted polyacrylamide theranostic nanoplatforms
The goal of this work was to modify the structural parameters of porphyrin-based agents to optimize their imaging and/or therapeutic potential. In order to achieve our goal, certain chlorins and bacteriochlorins were ...