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Brain as a Predictor of Learning in Entertainment-Education: An Event-Related Potential (ERP) Study
(State University of New York at Buffalo, 2018)
For decades now, entertainment media have been created to leverage the power of storytelling for raising social consciousness, disseminating accurate information, and facilitating positive change through the use of ...
Neural Mechanisms of Tinnitus and the Effects of Low-Level Noise Exposure on the Peripheral and Central Auditory Systems
(State University of New York at Buffalo, 2018)
Subjective tinnitus, the perception of ringing or buzzing without an external sound source, and hyperacusis, an intolerance to loud sounds, can be severely debilitating disorders, and unfortunately, there remains no cure. ...
Integrating Network Science and Computational Topology with Applications in Neuroscience Data Analytics
(State University of New York at Buffalo, 2018)
Real world systems are complex, dynamic and exist across multiple scales. Recent revolutions in data collection and storage have provided researchers with unprecedented access to information about these systems in greater ...
Characterization of novel alpha2/alpha3 subtype-selective GABAA receptor positive allosteric modulators
(State University of New York at Buffalo, 2019)
Millions of individuals endure persistent pain. In the United States alone, about 30% of the population is estimated to suffer from chronic pain. In addition to the physical and emotional burden that chronic pain imparts, ...
Magnetothermal Neuromodulation
(State University of New York at Buffalo, 2019)
To understand the phenotypical and aberrant aspects of brain functions, circuital elements within the brain need to be perturbed and the effects correlated. However, the fast dynamics and the complex heterogeneity of neural ...
Voltage-Gated Calcium Channels Function in Reactive Astrocytes
(State University of New York at Buffalo, 2019)
Astrocytes exhibit excitability in the form of intracellular Ca++ oscillations which are critical for the regulation of many cellular events (Cornell Bell et al., 1990). We previously reported that voltage-gated Ca++ ...
Cross-Sensory Perception in Music and Visual Media: A Neurocognitive Approach to Multimedia Counterpoint
(State University of New York at Buffalo, 2018)
Despite differences in language and methodology, the fields of music theory, multimedia studies, and cognitive neuroscience are exploring many of the same questions. This dissertation seeks to define and describe multimedia ...
Identification of Potential HTT-Rab Axonal Transport Complexes
(State University of New York at Buffalo, 2018)
Huntington’s disease (HD) is a deadly neurodegenerative disorder that is caused by an expansion of the poly-glutamine tract in the huntingtin (HTT) gene. Evidence has shown that HTT can function in the axonal transport ...
Opiate-Induced Plasticity in the Mesolimbic Dopamine System
(State University of New York at Buffalo, 2019)
Substance use disorder is a chronic, relapsing disease that results from cellular maladaptations within discrete regions of the mesolimbic dopamine system, or the ‘reward pathway.’ Two critical regions that are known to ...
Discovery and Pharmacological Characterization of Environmental Melatonin Receptor Modulators
(State University of New York at Buffalo, 2019)
Melatonin targets MT1 and MT2 melatonin receptors that are expressed in brain and peripheral tissues in order to signal “time-of-day” messages for the synchronization of circadian rhythms. In 2017, Popovska-Gorevski et al. ...