Search
Now showing items 1-10 of 19
Characterization of novel alpha2/alpha3 subtype-selective GABAA receptor positive allosteric modulators
(State University of New York at Buffalo, 2019)
Millions of individuals endure persistent pain. In the United States alone, about 30% of the population is estimated to suffer from chronic pain. In addition to the physical and emotional burden that chronic pain imparts, ...
Aberrant immune states of the inner ear resultant of aging and lower level noise
(State University of New York at Buffalo, 2018)
Cochlear immunity is an important process for cochlear homeostasis and diseases. Over the past twenty years, numerous researchers have investigated cochlear immunity as it pertains to inner ear stresses. However, the vast ...
Lipid Biomarkers in Multiple Sclerosis Pathogenesis
(State University of New York at Buffalo, 2018)
The purpose of the work presented in this dissertation was to investigate the role of cholesterol metabolism in the pathogenesis of multiple sclerosis (MS). Serum lipid profile measures have previously been shown to be ...
Magnetothermal Neuromodulation
(State University of New York at Buffalo, 2019)
To understand the phenotypical and aberrant aspects of brain functions, circuital elements within the brain need to be perturbed and the effects correlated. However, the fast dynamics and the complex heterogeneity of neural ...
Activity-dependent changes at the auditory nerve synapse
(State University of New York at Buffalo, 2018)
Information transfer at chemical synapses occurs when vesicles fuse and release neurotransmitter. This process is tightly regulated and must maintain stable function when faced with different levels of activity. Three main ...
Neural Mechanisms of Tinnitus and the Effects of Low-Level Noise Exposure on the Peripheral and Central Auditory Systems
(State University of New York at Buffalo, 2018)
Subjective tinnitus, the perception of ringing or buzzing without an external sound source, and hyperacusis, an intolerance to loud sounds, can be severely debilitating disorders, and unfortunately, there remains no cure. ...
The Roles of WT1 and BASP1 in the Development and Maintenance of the Posterior Taste Field
(State University of New York at Buffalo, 2018)
Taste is one of the fundamental senses that organisms have evolved, which is critical for survival. Taste receptor cells have the function to detect chemicals in the oral cavity and transmit the chemical information to the ...
Identification of Potential HTT-Rab Axonal Transport Complexes
(State University of New York at Buffalo, 2018)
Huntington’s disease (HD) is a deadly neurodegenerative disorder that is caused by an expansion of the poly-glutamine tract in the huntingtin (HTT) gene. Evidence has shown that HTT can function in the axonal transport ...
Cross-Sensory Perception in Music and Visual Media: A Neurocognitive Approach to Multimedia Counterpoint
(State University of New York at Buffalo, 2018)
Despite differences in language and methodology, the fields of music theory, multimedia studies, and cognitive neuroscience are exploring many of the same questions. This dissertation seeks to define and describe multimedia ...
Functional Regulation of Ion Channels in Dorsal Root Ganglion Neurons by Magi-1: Implications in Pain Signaling
(State University of New York at Buffalo, 2018)
Persistent pain leads to alterations in ion channel expression in neurons along the pain-axis. Ion channels provide neurons with a mechanism to detect and respond to changes in their environment. Adaptive changes in ion ...