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Pharmacokinetics and Receptor-Mediated Pharmacodynamics of Methylprednisolone
(State University of New York at Buffalo, 2019)
The corticosteroids possess substantial anti-inflammatory and immunomodulatory activity. Prolonged use of these drugs are, however, associated with adrenal suppression and other dose-limiting metabolic toxicities, manifested ...
Porphyrin-Phospholipid Liposomes for Chemophototherapy of Solid Tumors
(State University of New York at Buffalo, 2018)
Cancer is a major health care burden in the United States and all over the world. The effort of this thesis focuses on the development of doxorubicin encapsulated porphyrin-phospholipid (Dox-PoP) liposomes for the treatment ...
Lipid Biomarkers in Multiple Sclerosis Pathogenesis
(State University of New York at Buffalo, 2018)
The purpose of the work presented in this dissertation was to investigate the role of cholesterol metabolism in the pathogenesis of multiple sclerosis (MS). Serum lipid profile measures have previously been shown to be ...
Megalin, Cubilin, and FcRn Expression in Type 2 Diabetes: Implications for Pharmaceutics and Diabetic Kidney Disease
(State University of New York at Buffalo, 2019)
Monoclonal antibodies (mAbs) continue to lead protein therapeutics. However, very few studies have examined the impact of diabetes mellitus (DM), one of the most frequent disease states worldwide, on mAb disposition. ...
Deorphanizing Monocarboxylate Transporter 6: Evidence of Functional Roles in Lipid Metabolism and Drug Transport
(State University of New York at Buffalo, 2019)
Monocarboxylate transporters (MCTs) are members of the solute carrier 16 (SLC16) family of transporter proteins that are responsible for wide range of essential physiological processes. In total, there are fourteen isoforms ...
Toxicodynamic and Toxicokinetic Based Treatment of γ-Hydroxybutyric Acid (GHB) Overdose
(State University of New York at Buffalo, 2019)
γ-Hydroxybutyric acid (GHB) is a short chain fatty acid which was first discovered through its synthesis in 1874, and later found to be an endogenous compound in the human central nervous system. GHB is a structural analogue ...
Pharmacokinetics-Pharmacodynamics Based Investigations to Support the Development of Antibody-Drug Conjugates
(State University of New York at Buffalo, 2019)
Antibody-drug Conjugates (ADCs) are one of the fastest growing class of anticancer therapeutics, which consists of monoclonal antibodies (mAbs) covalently bound to highly potent chemotherapeutic agents (payloads) via ...
Investigation of Inter-Individual Variability in Monoclonal Antibody Disposition
(State University of New York at Buffalo, 2018)
Substantial inter-individual variability (IIV) in monoclonal antibody (mAb) pharmacokinetics has been reported in the clinic. The sources of variability are not well understood and often not explored. Very few preclinical ...
Biological Assessment of Thioamide and Amide-Containing Chalcogenorhodamine Dyes as Photosensitizers for PDT of Cancer, ECP, and GVHD & Synthesis and Evaluation of Oligothiophene-Containing Chalcogenorhodamine Dyes for Biological and Photochemical Applications
(State University of New York at Buffalo, 2018)
The synthesis of chalcogenorhodamine dyes having biological applications as photosensitizers for photodynamic therapy (PDT) of cancer, extracorporeal photopheresis (ECP) of malignant T-cells, and graft-versus-host disease ...
New Strategies to Enhance Immunotoxin Potency and Anti-Cancer Efficacy
(State University of New York at Buffalo, 2019)
The presented dissertation highlights development of immunoconjugate strategies that aim to deliver selectively and safely macromolecular toxins to treat colorectal cancer. Experimental observations and mathematical modeling ...