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Copper-Catalyzed Synthesis of Saturated Oxygen and Nitrogen Heterocycles by Alkene Difunctionalization
(State University of New York at Buffalo, 2019)
The complexity of the molecules are usually the factors contributing to their observed biological and physiological properties. Synthetic organic chemistry has been a tool used by achieving such complexity by starting from ...
Microfabricated tissue platforms for the study of biomechanics and tissue engineering
(State University of New York at Buffalo, 2019)
After the finding that cell fate (life and death) could be controlled by geometric design in 1997, people started to analyze the influence of mechanical stimuli to cells and tissue behavior. Later research found that proper ...
Development of Photoacoustic Imaging Technologies for Biomedical Applications
(State University of New York at Buffalo, 2019)
Photoacoustic imaging (PAI) is an emerging modality based on the acoustic detection of optical absorption. Since acoustic scattering in tissue is much less than that of light, the conversion of light absorption into sound ...
Dissecting the Role of Epithelial Mesenchymal Transition and 1,25(OH)2D3 Activity in EGFR-Mutant Tyrosine Kinase Inhibitor-Resistant Lung Cancer
(State University of New York at Buffalo, 2019)
The body of work presented here describes three in vitro models of EGFR-mutant TKI-resistant NSCLC derived from EGFR TKI-sensitive cell lines in our laboratory. Two cell lines, H1975-OR and SH416-ER, underwent EMT. H1975-OR ...
Bioorthogonal Chemistry for Protein Labeling in Live Cells
(State University of New York at Buffalo, 2018)
Chapter one provides an overview of bioorthogonal reactions commonly used in the chemical biology field. Chapter two describes the synthesis of a BODIPY-tetrazole and its use as an “off-on” reporter of hydrogen peroxide ...
Innovations in Test Phantom Metrology for Ultrasonic Imaging in relation to Medical Imaging, Biometric Characterization, and 3-Dimensional Microfluidic Applications
(State University of New York at Buffalo, 2018)
This dissertation discusses the design, fabrication, and testing of a series of test phantoms for the testing and validation of a series of applications. These test phantoms focused on the replications of key physiological ...
Ultra-Broad-Band Protocol Stack Design for Directional Terahertz Communication Networks
(State University of New York at Buffalo, 2019)
Terahertz (THz)-band (0.1-10 THz) communication is envisioned as a key wireless technology of the next decade, able to support wireless Terabit-per-second links in 6G systems. THz communication exhibits an extremely large ...
Understanding the Effects of Engineered Nanomaterials on Mammalian Cells and Plants Using a Mass Spectrometry Based Approaches
(State University of New York at Buffalo, 2019)
Nanotechnology focuses on the development and application of materials in the nanoscale range. Engineered nanomaterials (ENMs) are usually defined as particles of 1-100 nm in size in at least one dimension, which have been ...
Promoting Bipartisan Action to Mitigate Climate Change Impacts Through Psychological Distance Framing
(State University of New York at Buffalo, 2019)
Research shows that portraying climate change impact as psychologically close leads to greater concern about climate change. However, people’s intentions to engage in mitigation actions are not consistently influenced by ...
Investigation of Inter-Individual Variability in Monoclonal Antibody Disposition
(State University of New York at Buffalo, 2018)
Substantial inter-individual variability (IIV) in monoclonal antibody (mAb) pharmacokinetics has been reported in the clinic. The sources of variability are not well understood and often not explored. Very few preclinical ...