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Copper-Catalyzed Synthesis of Saturated Oxygen and Nitrogen Heterocycles by Alkene Difunctionalization
(State University of New York at Buffalo, 2019)
The complexity of the molecules are usually the factors contributing to their observed biological and physiological properties. Synthetic organic chemistry has been a tool used by achieving such complexity by starting from ...
Dissecting the Role of Epithelial Mesenchymal Transition and 1,25(OH)2D3 Activity in EGFR-Mutant Tyrosine Kinase Inhibitor-Resistant Lung Cancer
(State University of New York at Buffalo, 2019)
The body of work presented here describes three in vitro models of EGFR-mutant TKI-resistant NSCLC derived from EGFR TKI-sensitive cell lines in our laboratory. Two cell lines, H1975-OR and SH416-ER, underwent EMT. H1975-OR ...
Microfabricated tissue platforms for the study of biomechanics and tissue engineering
(State University of New York at Buffalo, 2019)
After the finding that cell fate (life and death) could be controlled by geometric design in 1997, people started to analyze the influence of mechanical stimuli to cells and tissue behavior. Later research found that proper ...
Development of Photoacoustic Imaging Technologies for Biomedical Applications
(State University of New York at Buffalo, 2019)
Photoacoustic imaging (PAI) is an emerging modality based on the acoustic detection of optical absorption. Since acoustic scattering in tissue is much less than that of light, the conversion of light absorption into sound ...
DYNAMICS AND APPLICATIONS OF PLASMONICALLY INDUCED RESISTANCE IN METAL NANOGRATINGS
(State University of New York at Buffalo, 2019)
This dissertation examines the mechanisms that enable the detection of surface plasmons using direct electronic measurements rather than established optical techniques, and considers potential applications that arise as a ...
Geometric Multigrid for Unstructured Finite Elements: Implementation and Applications
(State University of New York at Buffalo, 2019)
In the realm of computational science, a fundamental interest lies in our ability to construct models of complex phenomenon and probe them in order to gain understanding and make predictions about the systems at hand. ...
Development of a Stand Alone Comprehensive Collision Prediction System for Modern Radiation Therapy
(State University of New York at Buffalo, 2019)
Purpose: Studies exploring the use of non-coplanar radiotherapy involving unconventional combinations of treatment couch and gantry orientations have demonstrated significant dosimetric benefits. However, clinical ...
A MULTISCALE STUDY OF CONCRETE SUBJECTED TO ELEVATED TEMPERATURES
(State University of New York at Buffalo, 2019)
Low aspect ratio, shear-critical, reinforced concrete walls are used in nuclear power plants to resist gravity and lateral forces, and some serve a containment function. Beyond design basis earthquake shaking has the ...
Mass gap in weakly coupled Abelian Higgs on a unit lattice
(State University of New York at Buffalo, 2019)
We study the problem of mass generation in particle physics. In the Standard Model, the interaction of a particle with the Higgs boson is responsible for its mass generation, known as the Higgs mechanism. Our model is a ...
Tender Trades: Wet Nursing, Urban Domestic Economies & the Intimate Politics of Inequity in the Anglo-Atlantic, 1750-1815
(State University of New York at Buffalo, 2019)
This dissertation explores the process of class- and race-formation within the private homes of the respectable classes and those who aspired to respectability in late-eighteenth-century London and Philadelphia. It finds ...