Now showing items 1-10 of 86
Molecular mechanism of inhibitor of kappa B kinase (IKK) complex activation by inducible phosphorylation and ubiquitination upon T cell receptor (TCR) stimulation
IκB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ/NEMO. The activation of IKK complex ...
Impact of aging on type I collagen and transforming growth factor-beta1 (TGF-beta1) mRNA expression during muscle degeneration
We tested the hypothesis that type I collagen mRNA expression would be lower in injured skeletal muscle from senescent rats compared with young and middle-aged rats, and that this decrease would be associated with a decreased ...
Effects of TNF-alpha on type I collagen and TGF-beta1 mRNA expression in muscle cells
The purpose of this study was to determine whether treatment of cultured C 2 C 12 myoblasts and mytotubes with TNF-α over time (24, 48 and 72hrs) would stimulate collagen metabolism either directly or indirectly through a ...
Development and evaluation of a new high-sensitivity, region-of-interest, x-ray imaging system for neuro-interventional applications
Neurovascular image-guided interventional (IGI) procedures require very high resolution (3 to 10 lp/mm), large dynamic range, and real-time imaging capability for visualization and navigation of endovascular devices during ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Protoporphyrinogen oxidase (PPOX) targeted gene silencing based photodynamic therapy (PDT) in combination with photofrin-PDT
Photodynamic therapy ( PDT ) has proved to be an effective approach for the treatment of solid tumors. Tumors are treated with an exogenous photosensitizer and the photosensitizer is excited using light. The excited ...
Production of polyclonal antibodies to late erythroblast-3 (LEB-3), a protein expressed during erythropoiesis and spermatogenesis
Previous studies in the lab identified a number of partial messenger RNAs (mRNAs) that are differentially expressed at the later as opposed to early stages of the production of red blood cells (terminal erythroid ...
Spatio-temporal landscape models for West Nile virus vector population abundance and distribution
In response to the rapid spread of West Nile virus throughout North America there has been an increase in the number of mosquito vector surveillance and control programs. However, mosquito surveillance programs are costly ...
Cadmium and mercury suppress cytokine receptor-mediated Jak/STAT activation by inhibiting mitochondrial function and increasing intracellular oxidative stress
The Janus kinase (Jak)/signal transducer and activator of transcription (STAT) pathway is an intercellular signal transduction mechanism that acts in many cell types, including neurons, during development and repair after ...
Microarray and real time-polymerase chain reaction analysis of mammary glands from rats fed conjugated linoleic acid
Conjugated linoleic acid (CLA) prevents mammary tumors in rats. The purpose of this study was to test the hypothesis that common pathways are altered by two similarly chemoprotective isomers, 9,11-CLA and 10,12-CLA. ...