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The role of Thoc1 in prostate cancer and the functional significance of Rb/Thoc1 interaction
(2010)
Thoc1 is highly expressed in breast cancer, non-small cell lung cancer and familial adenomatous polyposis. Cancer cells and oncogene-transformed fibroblasts undergo apoptosis upon loss of Thoc1 while normal fibroblasts do ...
Breast epithelial morphogenesis: The role of annexins and primary cilia
(2014)
Models of three dimensional (3D) mammary acinar morphogenesis are extensively used to study oncogenic transformation of breast epithelial cells. Using these models, factors and mechanisms that lead to aberrant 3D acinar ...
A study comparing the effects of continuous and cyclic oral contraceptive treatments on mammary gland microenvironment and tumor progression in BALB/c mice using the 4T1 transplantation model
(2014)
Cyclic oral contraceptives (OC), although effective at preventing uterine and ovarian cancers, increase breast cancer risk. However, the effects of extended use (continuous) OC on breast cancer risk are unknown. We hypothesize ...
Estrogen receptor (ER) alpha-mediated regulation of the p53-targets MDM4, MDM2 and NOXA in human breast cancer
(2015)
In this dissertation, I present the results of my investigation of the ability of ERα/ESR1 to regulate the p53-regulated proteins MDM2, MDM4 and NOXA/PMAIP1 in human breast cancer, and I discuss these findings in the context ...
Effects of chronic alcohol consumption and folate supplementation on the mouse mammary gland
(2009)
Chronic alcohol consumption is a strong risk factor for breast cancer development in women. One potential mechanism linking alcohol and an increased risk of breast cancer development includes the ability for alcohol to ...
Structural characterization of JAA-F11-Fab by X-ray crystallography
(2007)
Thomsen Friedenreich antigen (TF-Ag), is a carbohydrate antigen found on many types of tumors, including breast, prostate, bladder and ovarian. Passive transfer of JAA-F11, a monoclonal anti-TF-Ag antibody, has been shown ...
Regulation of hippo signaling by PTPN14 and KIBRA and the role of TAZ in mammary development and tumorigenesis
(2017)
A key feature of the mammary gland is that it doesn’t fully develop until after birth. This allows for the use of mouse models as unique tools to study development and organ specificity. Processes involved in mammary gland ...
The role of family history and risk of breast cancer aggressiveness in African American and European American women
(2013)
INTRODUCTION: European-American (EA) women, overall, have higher breast cancer incidence than African-American (AA) women. However, AA women are more likely to be diagnosed at a younger age and to have more aggressive ...
Smad3 mediates TGF-beta induced apoptosis through the control of survivin expression in human breast cancer cells
(2005)
Transforming growth factor-β (TGF-β) pathway initiates signaling by assembling receptor complexes that activate Smad transcription factors. TGF-β plays a key role in cell proliferation, differentiation and apoptosis. The ...
Supplement use, physician recommendations, and chemotherapy-induced peripheral neuropathy in a breast cancer clinical trial
(2015)
Dietary supplement use during chemotherapy is controversial, partly due to the potential effect of antioxidants on reduced efficacy of chemotherapy-related cytotoxicity. We examined supplement use among breast cancer ...