Now showing items 101-103 of 103
A novel type of non-PK related genes controls susceptibility to the toxic effects of irinotecan
Adverse drug reactions (ADRs) are a major obstacle in cancer chemotherapy. In spite of the advances in the development of anti-cancer drugs, ADRs compromise their potential benefits in many patients by imposing reduction ...
Glycopeptide probes of PSGL-1 to study site-specific glycosylation and stem cell homing function
This dissertation represents an effort to develop tools to study the glycosylation of a mucinous protein called P-selectin glycoprotein ligand-1 (PSGL-1). This protein is a key adhesion molecule in inflammation and immunity. ...
Trap-mediated transcription termination within the b. Subtilis trp operon leader region
Transcription of the tryptophan operon in Bacillus subtilis is regulated by an attenuation mechanism involving competing RNA secondary structures. trp RNA-binding attenuation protein (TRAP) binding to a site within the ...