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Protoporphyrinogen oxidase (PPOX) targeted gene silencing based photodynamic therapy (PDT) in combination with photofrin-PDT
(2007)
Photodynamic therapy ( PDT ) has proved to be an effective approach for the treatment of solid tumors. Tumors are treated with an exogenous photosensitizer and the photosensitizer is excited using light. The excited ...
Production of polyclonal antibodies to late erythroblast-3 (LEB-3), a protein expressed during erythropoiesis and spermatogenesis
(2007)
Previous studies in the lab identified a number of partial messenger RNAs (mRNAs) that are differentially expressed at the later as opposed to early stages of the production of red blood cells (terminal erythroid ...
Psychometric properties of an instrument designed to assess long-term risk perceptions about the Chernobyl disaster among Belarusians
(2006)
The 1986 nuclear reactor meltdown in Chernobyl, Ukraine remains one of the largest and most notable human-made environmental disasters. Radiation contamination from the disaster was widespread, with the greatest concentrations ...
A comparative study of photosensitizers with and without carbohydrate moieties
(2006)
Many potentially useful photosensitizers for the photodynamic therapy (PDT) of malignancies have poor tumor selectivity. We hypothesized that certain carbohydrates on conjugating with photosensitizers at the optimal position ...
Histatin 5 targets Trk1 potassium transporter and leads to osmotic stress response in Candida albicans
(2006)
Human salivary Histatins are a family of small histidine-rich peptides with potent antifungal activity against Candida species and other pathogenic yeasts. Their fungicidal mechanisms are initiated by binding to the cell ...
Glycogen synthase kinase 3 regulates NMDA receptor channel trafficking and function in cortical neurons
(2006)
Emerging evidence has suggested that glycogen synthase kinase 3 (GSK-3) is a key regulatory kinase involved in a plethora of processes in the nervous system including neuronal development, mood stabilization and ...
The role of differential glyco-gene expression in cancer metastasis
(2006)
Metastasis involves invasion, intravasation, transport, arrest, extravasation, secondary growth, and angiogenesis. To study carbohydrate-mediated interactions in these processes, four closely-related murine mammary carcinoma ...
Integrated feature subset selection/extraction with applications in bioinformatics
(2006)
Feature subset selection and extraction algorithms are actively and extensively studied in machine learning literature to reduce the dimensionality of feature space, since high dimensional data sets are generally not ...
Tryptophan-induced activation of TRAP in Bacillus subtilis
(2006)
The tryptophan biosynthetic operon in Bacillus subtilis and other related bacilli is negatively regulated by an RNA binding protein called TRAP ( trp RNA-binding attenuation protein). TRAP is composed of eleven identical ...
Mitochondria-wide screening of genes involved in protection against arsenic toxicity in Saccharomyces cerevisiae
(2006)
Epidemiological studies have suggest a significant increase in the risk of various cancers on exposure to arsenic. The mechanism(s) of arsenic carcinogenesis in humans is poorly understood. In this research, we have employed ...