Now showing items 11-20 of 40
Use of fibrin hydrogels for localized and cell-controlled lentiviral gene delivery
Recombinant lentiviruses are efficient gene delivery vehicles with the ability to infect non-dividing cells including neurons, hematopoietic and embryonic stem cells. In addition to high efficiency several applications may ...
Metabolic engineering of Escherichia coli and Saccharomyces cerevisiae to mutasynthesize natural phenylpropanoids and novel analogs
The current dissertation investigated the biosynthesis of natural and unnatural flavonoids using Escherichia coli and Saccharomyces cerevisiae. Flavonoids are a diverse group of secondary metabolites found ubiquitously in ...
A screw-theoretic framework for musculoskeletal system modeling and analysis
This thesis will address the development of tools for musculoskeletal system analysis, leveraging methodologies which have revolutionized the engineering domains. In particular, screw-theoretic modeling and analysis ...
High yield anthocyanin biosynthesis in metabolic engineering Escherichia coli
Anthcoyanins, the largest sub-group of flavonoids and a major group of plant pigments, impart the eye-catching hues to most flowers and fruits ranging from pink through red and purple to dark blue. They are widely distributed ...
A web-based modeling approach for tracking algal blooms in lower Great Lakes
The occurrence of algal blooms in the Great Lakes has been a growing concern over the past few decades, especially for toxic or harmful algal blooms (HABs). For the present work a general circulation model is used to help ...
Structure-property relationships in associating polymer solutions
Abstract not available.
Optimization and regulation of insulin expression from genetically modified skin cells
It has been shown that genetically modified keratinocytes (skin stem cells) can secrete proteins less than 16 kDa via the capillaries to the blood stream. Here we demonstrate that human epidermal keratinocytes can be ...
Endothelial cell layer subjected to flow mimicking the apex of an arterial bifurcation
Endothelial cell response to shear stress and shear stress gradients is widely accepted as a mediator of vascular pathology, including intracranial aneurysms. To this point, most in vitro research on endothelial cells ...
Analysis of TGF-mediated dynamics in a system of many coupled nephrons
Previously, Pitman et al. (2002) derived an integral model of the tubuloglomerular feedback system. This integral model (also known as reduced model) describes the fluid flow up the thick ascending limb of a single, ...
Pulsed adsorption gas sensor system
Volatile organic compounds are known to cause harm to humans and are ever present in varying concentrations around us. Studies show that the levels of concentration of volatile organics are far greater indoors than outdoors ...