Now showing items 11-20 of 40
Optimization and regulation of insulin expression from genetically modified skin cells
It has been shown that genetically modified keratinocytes (skin stem cells) can secrete proteins less than 16 kDa via the capillaries to the blood stream. Here we demonstrate that human epidermal keratinocytes can be ...
Structure-property relationships in associating polymer solutions
Abstract not available.
High yield anthocyanin biosynthesis in metabolic engineering Escherichia coli
Anthcoyanins, the largest sub-group of flavonoids and a major group of plant pigments, impart the eye-catching hues to most flowers and fruits ranging from pink through red and purple to dark blue. They are widely distributed ...
Efficient retroviral transduction of human epidermal stem cells using recombinant fibronectin
The epidermis is an attractive target for gene therapy because it is easily accessible and shows great potential as an ectopic site for protein delivery in vivo. Genetically modified epidermal keratinocytes are used to ...
Endothelial cell layer subjected to flow mimicking the apex of an arterial bifurcation
Endothelial cell response to shear stress and shear stress gradients is widely accepted as a mediator of vascular pathology, including intracranial aneurysms. To this point, most in vitro research on endothelial cells ...
Blood flow measurement from digital angiography
Computational fluid dynamic (CFD) simulations are emerging as a promising tool for diagnosis and treatment planning of vascular diseases such as intracranial aneurysms. In addition to the three-dimensional luminal geometry, ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Theoretical and experimental investigation of gap junctional conductance and permeability
Gap junctions are intercellular pores providing the primary means for direct exchange between cells, of ions and metabolites up to molecular weights of about 1000. They are essential for normal physiological function and ...
High yields of natural products in recombinant microorganisms using regulatory factors
Control of genetic expression, which is traditionally considered as protein's job, can also be achieved by small mRNA sequences located in 5'-UTR of any gene widely recognized as 'riboswitches'. These riboswitches control ...
Biophysical effects of dimyristoylphosphatidylserine on electroporation-induced skin transport regions
DMPS is known to enhance the transdermal transport of small polar solutes by electroporation significantly. Understanding the modus operandi of this enhancement is essential for the further improvement and development of ...