Now showing items 11-20 of 137
Computer Modeling of Neurovascular Flow Diverter
Intracranial aneurysm rupture is one of the main contributors (15%) to subarachnoid stroke, which is identified as the third deadliest disease in North America. Among current widely used treatment strategies, flow diversion ...
Selective targeting of cell signaling and inflammatory proteins using biologics
The dissertation is divided into three sections: The first part describes the engineering of fibronectin type III (FN3) monobodies to target the ERK-2 signaling pathway. ERK-2, along with other mitogen activated protein ...
A Role for Hippocampal Tumor Necrosis Factor-α (TNF) Production in Streptozotocin (STZ)-Induced Diabetic Neuropathy
In the central nervous system, the pro-inflammatory cytokine and protein mediator, Tumor Necrosis Factor (TNF), plays an important role in development of neuropathic pain. Studies have shown that suppression of TNF in the ...
Mathematical Modeling of N-Glycosylation: Model Construction and Parameter Estimation from Mass Spectra of Chinese Hamster Ovary Cell Mutants
Colossal advances in molecular cellular biology have witnessed the growth of genomics, proteomics and other "–omics" fields, built on reductionist approaches aimed at annotating a vast array of biological components, from ...
System-level modeling and analysis of biological reaction networks in signal transduction and glycosylation
Novel high-throughput genomic and proteomic tools are allowing the integration of information from a range of biological assays into a single conceptual framework. This framework is often described as a network of biochemical ...
The effect of operational parameters on the fate of tetracycline resistant bacteria in biological wastewater treatment plants
The main focus of this research is to study the fate of antibiotic resistant organisms in biological treatment processes as a function of operation and antibiotic presence. Data generated as a part of this study are expected ...
Blood flow measurement from digital angiography
Computational fluid dynamic (CFD) simulations are emerging as a promising tool for diagnosis and treatment planning of vascular diseases such as intracranial aneurysms. In addition to the three-dimensional luminal geometry, ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Development and evaluation of a new high-sensitivity, region-of-interest, x-ray imaging system for neuro-interventional applications
Neurovascular image-guided interventional (IGI) procedures require very high resolution (3 to 10 lp/mm), large dynamic range, and real-time imaging capability for visualization and navigation of endovascular devices during ...
Effect of fat on inflammation and insulin resistance in human mononuclear cells and myeloid cell insulin receptor knockout mice
Obesity and diabetes are major risk factors for cardiovascular disease. Both have been shown to be associated with oxidative stress and inflammation. These processes are also involved in the pathogenesis of atherosclerosis. ...