Now showing items 11-20 of 164
Vitamin C and collagen IV formation in fibroblasts
Collagen IV (Col4) is a major component of vascular basement membranes (BM). Mice expressing mutated Col4 died shortly after birth with cerebral hemorrhage. Mice lacking the ubiquitous vitamin C (Asc) transporter SVCT2 ...
Molecular mechanisms regulating DeltaNp63 expression and function during development and differentiation of mouse skin keratinocytes
The skin is a multilayered stratified epithelium providing a protective barrier against dehydration and pathogenic insult. The transcription factor p63 plays an important role in the development of stratified epithelium ...
Robust microbial fabrication of plant pharmaceuticals: Complexities and solutions
Abstract not available.
Applications of the 1,3-dipolar cycloaddition reaction towards the target guided synthesis of small molecule inhibitors and towards peptide stapling
Based on the structure of the known MDM2 inhibitor Nutlin, a series of pyrazoline and pyrazole compounds were synthesized and tested in an ELISA test format, from which 1,5-Bis-( 4-chloro-phenyl)-3-(2-isopropoxy-4-methox ...
Lipoprotein signaling & cholesterol metabolism associated gene expression in human ovarian granulosa cells during IVF
Background: In vitro fertilization (IVF) is an inefficient process. Better biomarkers are required to improve the selection of oocytes and embryos and thereby increase the efficiency of this procedure. Follicular cholesterol ...
Expression of Wnt signaling pathway genes during erythroid terminal differentiation (ETD)
Background: Erythropoiesis is a complex multistep process whereby nucleated erythroid progenitor cells differentiate into enucleated red blood cells. The processes of proliferation, differentiation and apoptosis are balanced ...
Association of a novel pre-ribosomal complex in Trypanosoma brucei
In eukaryotes, 5S rRNA is transcribed in the nucleoplasm and requires the ribosomal protein L5 to deliver it to the nucleolus for ribosome assembly. Trypanosome-specific proteins P34 and P37 form a novel preribosomal complex ...
Unique enzymatic properties of human ST3Gal sialyltransferases: Reversible sialylation and synthesis of CMP-sialic acid in human blood
Glycosylation is a ubiquitous posttranslational modification found on most secretory proteins that are either soluble or that are cell surface bound. Structures formed as a result of glycosylation regulate biological ...
Drug Target Identification and Elucidation of Mechanism of Action of ARKILs
Prostate cancer cells require the transcription factor Androgen Receptor (AR) for their growth and survival. The current standard of care for patients diagnosed with prostate cancer is anti-androgen therapy, which is not ...
Assessing PDT response with diffuse optical spectroscopies
Photodynamic therapy (PDT) is used to treat a variety of conditions including cancer. Effective PDT requires three components: a photosensitizer (PS), light of a specific wavelength to activate the PS and oxygen. When all ...