Now showing items 11-16 of 16
Study of Reg Signaling in Mouse Cardiac Tissue
Background : The Reg signaling pathway is well known to promote proliferation, differentiation and/or to protect cells from apoptosis (programmed cell death) in various organs, such as the pancreas, neuronal tissue, ...
R Packages for density based empirical likelihood based hypothesis tests
This thesis presents the functionality of two new R packages for performing goodness-of-fit tests based on density based empirical likelihood methods: dbEmpLikeGOF and dbEmpLikeNorm. The dbEmpLikeGOF function dbEmpLikeGOF ...
Contribution of cytoskeletal stresses to cell volume regulation
Cells in the kidney collecting duct experience changes in extracellular osmolarity as urine flows out of the nephron. These changes impart osmotic forces on collecting duct epithelia, causing variations in cell volume. ...
Selective targeting of cell signaling and inflammatory proteins using biologics
The dissertation is divided into three sections: The first part describes the engineering of fibronectin type III (FN3) monobodies to target the ERK-2 signaling pathway. ERK-2, along with other mitogen activated protein ...
Magnetic stimulation of neurons and study of membrane structures
In the work presented in this dissertation, two novel techniques have been developed: i) a magnetic remote stimulation method for remotely triggering ion channel opening and neuron firing, and ii) binned-imaging fluorescence ...
Developing a Singlet Oxygen Responsive Molecular Beacon Based on a Binuclear Ruthenium (II) Polypyridyl Complex
As a developed fluorescent reporter, molecular beacons have been applied to various situations for biological detection via fluorescence quenching/restoration. Photodynamic molecular beacons generate singlet oxygen in ...