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Quantum mechanical effects in gravitational collapse
In this thesis we investigate quantum mechanical effects to various aspects of gravitational collapse. These quantum mechanical effects are implemented in the context of the Functional Schrödinger formalism. The Functional ...
I:- Design, synthesis and study of nucleotide prodrugs. II:- Synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU) and study of its mechanism of action as a thymidine phosphorylase inhibitor. III:- Design and synthesis of novel nucleotide analogs as alternative substrates for studying the mechanism of the thymidylate synthase-catalyzed reaction.
CHAPTER I: Design, synthesis and study of nucleotide prodrugs. In the past, several phosphate masking strategies have been developed with the objective of delivering nucleoside monophosphates into cells for improving the ...
Analysis and fate of pharmaceuticals and quantum dots as emerging contaminants in the aquatic environment
Environmental contaminants such as pharmaceutical residues and nanomaterials are an ecological concern as they pose potential undesirable effects on the biota. Pharmaceutical compounds and their metabolites are detected ...
Two classes of virtually fibered Montesinos links of type SL2
We find two new infinite families of virtually fibered Montesinos links of type [special characters omitted].
Analysis of PBDEs, PCBs and their metabolites in environmental and biological samples by gas and liquid chromatography with mass spectrometric detection
Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants that are found in the environment since the 1970’s due to its heavy usage in transformers and paints. PCBs are highly lipophilic and tend to ...
Taurodeoxycholic acid stimulates cholangiocyte potassium channels
Liver bile duct epithelial cells (cholangiocytes) are responsible for producing the HCO 3 -rich solution which alkalinizes bile and promotes bile flow to the duodenum. Basolateral membrane K + channels found in cholangiocytes ...
Evaluation of binary intermediate endpoints for their departure from perfect surrogacy
Methods of evaluating and validating potential surrogate variables have received considerable attention in the statistical and medical literature. While there is an implicit recognition of a connection with path analysis, ...
On the use of excess entropy scaling to describe the dynamic properties of molecular fluids
Relationships between thermodynamic and kinetic properties of molecular fluids have a wide variety of applications. The development of these relationships provides a means to predict one property based upon knowledge of ...
Extensions for the use of the epsilon -skew -normal distribution for modeling data
A common assumption for a number of statistical applications involving continuous data, is to assume the data are normally distributed. In the event the normality assumption is in question Box-Cox transformations to the ...
Gonadotropin stimulated apolipoprotein A-IV gene expression in human ovarian granulosa cells in vitro
Background. There is increasing evidence that high density lipoprotein (HDL) metabolism is important to mammalian female fertility. HDL is the sole lipoprotein in human ovarian follicular fluid (FF) and FF-HDL levels have ...