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Now showing items 21-30 of 32
Regulation of hormone responsive cancers by Ca 2+ /calmodulindependent protein kinase kinase 2
(2013)
Steroid Receptors (SR) are oncogenic drivers of proliferation in hormonally regulated cancers. Immunohistochemistry (IHC) studies have shown high expression levels of Ca2+/calmodulin-dependent kinase kinase 2 (CaMKK2), an ...
The role of CaMKK2 in prostate cancer progression
(2013)
The androgen receptor (AR) plays a critical role in prostate cancer (PC) progression; however, the molecular mechanisms by which the AR regulates cell proliferation in androgen-dependent and castration-resistant PC (CRPC) ...
Transcriptional regulation by WT1-BASP1 complex and the role of WT1 in taste cell development
(2013)
The Wilms's tumor 1 gene (WT1) encodes a zinc finger transcription factor that directs the development of several organs and tissues. As a transcriptional regulator, WT1 can either activate or repress numerous target genes ...
The characterization and removal of surgical smoke produced by electrosurgical and laser devices
(2013)
The main focus of this study was to characterize the physical and chemical make-up of ESU and diode laser surgical smoke produced from different tissue types, and the efficacy of the Turbo smoke extractor in reducing smoke ...
Overcoming Obstacles to Naïve T Lymphocyte Trafficking in Anti-Tumor Immunity
(2013)
Tumor-draining lymph nodes (TdLN) are the primary sites of generation of anti-tumor immunity, and thus, have emerged as key contributors to the efficacy of cancer treatment during chemotherapy, radiation, surgery, and ...
Respiratory Muscle Training Improves Exercise Endurance at Altitude
(2013)
People have been traveling to high altitude for centuries where they are faced with adverse environmental conditions. As one ascends to elevation, the barometric pressure is reduced and the air gets thinner. These changes ...
The evolutionary history of the extracellular calcium-sensing receptor and its role in skeletal development
(2013)
As one of the most interesting members of the G protein-coupled receptor (GPCR) superfamily of proteins, the calcium-sensing receptor (CaSR) is restricted in its presence to the chordate-vertebrate lineage, pointing to an ...
A characterization of the NTCU mouse model of lung squamous cell carcinoma: The role of vitamin D
(2013)
Lung cancer has the highest rate of mortality amongst the major cancer subtypes, in part due to the limited number of effective screening methods or treatment modalities, which leads to late stage diagnoses and progression ...
Insights into Colonization, Transformation and the Transition to Disease of Streptococcus pneumoniae And Possible Targets for Therapeutic Interventions
(2013)
The studies described in this thesis explore the physiology of upper respiratory tract colonization by S. pneumoniae and S. pyogenes. We have shown that colonization is associated with biofilm formation and examined the ...
A Role for Hippocampal Tumor Necrosis Factor-α (TNF) Production in Streptozotocin (STZ)-Induced Diabetic Neuropathy
(2013)
In the central nervous system, the pro-inflammatory cytokine and protein mediator, Tumor Necrosis Factor (TNF), plays an important role in development of neuropathic pain. Studies have shown that suppression of TNF in the ...