Now showing items 21-25 of 25
Optimization of tumor-imaging and therapeutic potential of near-infrared multifunctional agents, and targeted polyacrylamide theranostic nanoplatforms
The goal of this work was to modify the structural parameters of porphyrin-based agents to optimize their imaging and/or therapeutic potential. In order to achieve our goal, certain chlorins and bacteriochlorins were ...
Heterologous NH2-terminal basolateral targeting sequence for multipass transmembrane protein in epithelial cells
Sodium-dependent vitamin C transporters (SVCTs), SVCT1 and SVCT2, share 66% identical amino acid sequence but differentially localize to the apical and basolateral surface in MDCK cells, respectively. The N-terminal sequence ...
Identification of sufficient basolateral-targeting sequence in N-terminus of human sodium-dependent vitamin C transporter 2
Human sodium-dependent vitamin C transporters, hSVCT1 and hSVCT2 are responsible for the uptake of L-ascorbic acid in the body. Sharing 66% amino acid sequence homology, these two transporters are functionally localized ...
Potential Role of the GLUT4 Tether TUG in AMPK-mediated Glucose Uptake
Type 2 diabetes is quickly growing into an epidemic. Often known for its hyperglycemic state, type 2 diabetes also leads to dyslipidemia, β-cell dysfunction, and increased inflammation. These characteristics make the ...
Analysis of the biosynthesis and function of a serotype B glycoform of Moraxella catarrhalis lipooligosaccharides
Moraxella catarrhalis is an important human pathogen and a major cause of otitis media in children and respiratory infection in adults with chronic obstructive pulmonary disease (COPD). Few virulence factors have been ...