Now showing items 21-25 of 25
Heterologous NH2-terminal basolateral targeting sequence for multipass transmembrane protein in epithelial cells
Sodium-dependent vitamin C transporters (SVCTs), SVCT1 and SVCT2, share 66% identical amino acid sequence but differentially localize to the apical and basolateral surface in MDCK cells, respectively. The N-terminal sequence ...
Vitamin C and collagen IV formation in fibroblasts
Collagen IV (Col4) is a major component of vascular basement membranes (BM). Mice expressing mutated Col4 died shortly after birth with cerebral hemorrhage. Mice lacking the ubiquitous vitamin C (Asc) transporter SVCT2 ...
Anti-cancer activity of novel camptothecin analogues that are insensitive to ABCG2
Analogues of camptothecin (CPT) have been used in the clinic for almost two decades. The first analogue to be approved, topotecan (TPT), is now approved for use in patients with advanced ovarian, cervical, or small cell ...
Optimization of tumor-imaging and therapeutic potential of near-infrared multifunctional agents, and targeted polyacrylamide theranostic nanoplatforms
The goal of this work was to modify the structural parameters of porphyrin-based agents to optimize their imaging and/or therapeutic potential. In order to achieve our goal, certain chlorins and bacteriochlorins were ...
Identifying and Overcoming Mechanisms of Impaired Myogenic Differentiation in Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and adolescents, and is thought to represent abortive myogenic differentiation due to histology and expression of skeletal muscle-specific factors. ...