Now showing items 351-356 of 356
Effects of fever-range temperature on Ag-specific CD8+ T cell activation, differentiation and effector function
T lymphocytes normally become activated through interactive signals generated at the plasma membrane in response to antigen presentation. This activation is accompanied by the aggregation of cholesterol domains in the ...
Genomic study of human glial progenitor development
The broad aim of this research project was to understand molecular signals which underlie the development of human oligodendrocytes. Oligodendrocytes, which are responsible for producing myelin in the brain, are lost in ...
Identification of sufficient basolateral-targeting sequence in N-terminus of human sodium-dependent vitamin C transporter 2
Human sodium-dependent vitamin C transporters, hSVCT1 and hSVCT2 are responsible for the uptake of L-ascorbic acid in the body. Sharing 66% amino acid sequence homology, these two transporters are functionally localized ...
The roles of metabotropic GABA receptor in retina circuitry
GABAergic amacrine cell feedback to bipolar cells has been described, activating both GABA A and GABA C receptors. We explored whether metabotropic GABA B receptors also participate in this feedback pathway. Two approaches ...
Pharmacokinetics and lymphatic absorption of the protein VEGF-C156S
Lymphedema is a disorder of the lymphatic vascular system characterized by lymphatic insufficiency that leads to blockade of lymph flow and swelling of the extremities. VEGF-C156S is a recombinant mutant form of human ...
Heterologous NH2-terminal basolateral targeting sequence for multipass transmembrane protein in epithelial cells
Sodium-dependent vitamin C transporters (SVCTs), SVCT1 and SVCT2, share 66% identical amino acid sequence but differentially localize to the apical and basolateral surface in MDCK cells, respectively. The N-terminal sequence ...