Now showing items 31-33 of 33
Identifying and Overcoming Mechanisms of Impaired Myogenic Differentiation in Alveolar Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children and adolescents, and is thought to represent abortive myogenic differentiation due to histology and expression of skeletal muscle-specific factors. ...
Identifying and Targeting Mechanisms of Resistance to BRAF Inhibitors
Cutaneous melanoma is the most fatal type of skin cancer. The steady increase in incidence and static mortality rates have intensified the need to improve melanoma therapeutics. Constitutive activation of the growth signaling ...
Exploring the Role of Dicer in the Cellular Response to Mild (39.5°C) Hyperthermia Stress
Thermotolerance is a biological phenomenon wherein ‘mild hyperthermia experienced’ cells achieve a transient state of resistance to a subsequent heat shock insult. A thermotolerant phenotype is thought to be sustained ...