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Intramuscular vascular endothelial growth factor therapy for heart failure: Roles of host derived factors and mobilization of bone marrow progenitor cells
(2012)
Heart failure is a significant cause of morbidity and mortality worldwide. Currently, the only curative therapy for heart failure is heart transplantation and therefore alternative therapies are needed. Vascular endothelial ...
Efficient novel nonparametric tests and estimations with applications to biomedical studies
(2012)
Likelihood is arguably the most important concept for statistical inference in parameter models. The Neyman-Pearson lemma states that the likelihood ratio test is the most powerful test when the likelihood functions are ...
The Role of Nfib in Lung Development
(2012)
In vertebrates, the Nuclear factor I (NFI) transcription factor family consists of four genes ( Nfia, Nfib, Nfic and Nfix ) that regulate the development of multiple organs. During lung development, Nfib is expressed ...
Prostate-specific antitumor effects of natural compounds: Isoliquiritigenin and alternol
(2012)
Prostate cancer is the most commonly diagnosed form of cancer among men in the United States. It is second only to lung cancer as the leading cause of cancer-related deaths in males. The lethality of prostate cancer can ...
Imaging-guided preclinical trials of vascular targeting in prostate cancer
(2014)
Purpose: Prostate cancer is the most common non-cutaneous malignancy in American men and is characterized by dependence on androgens (Testosterone/Dihydrotestosterone) for growth and survival. Although reduction of serum ...
Application of Click Chemistry Towards The Synthesis of Bifunctional Stapled Peptides
(2013)
Cocktail therapies in cancer treatment are proven to be effective. Compared with cocktail therapies, fused bifunctional peptides are more predictable for their pharmacokinetic properties and potentially synergistic. Here, ...
Emerging Environmental Contaminants and the Metabolic Effects of Exposure Investigated by Mass Spectrometry
(2014)
Contaminants released into the environment at very low concentrations pose special analytical and toxicological challenges. Low concentrations require long exposures or very sensitive tests to assess the potential toxic ...
Expression changes of canine transporter targeting-related genes during epithelial cells differentiation determined by microarray analysis and RT-PCR
(2014)
The establishment and continuous renewal of differentiated apical and basolateral plasma membrane domains with distinct transporters play important roles in maintaining functions of epithelial cells. This process is initiated ...
The cis-trans regulatory circuit mediating RTK/Ras signaling in visceral muscle founder cell specification
(2014)
Cell fate specification is a fundamental approach for a cell to acquire unique identity from a group of undifferentiated cells during metazoan development, and it requires fine transcriptional regulation of target genes ...
The Selective Recognition of Thymine in Bulged and G-quadruplex DNA With Modified Zn(II) Macrocyclic Complexes
(2015)
The recognition of DNA secondary structures, which contain non-canonical thymines, using Zn(II) complexes will be presented. In particular, the binding to thymines found in bulge, hairpin and G-quadruplex DNA secondary ...