Search
Now showing items 31-40 of 164
Noradrenergic modulation of dopamine transmission evoked by electrical stimulation of the locus coeruleus in the rat brain
(2015)
Norepinephrine (NE) and dopamine (DA), the two major catecholamines (CA) in the central nervous system (CNS), have been implicated in a variety of physiological functions and behaviors. Particularly, noradrenergic neurons ...
Drug Target Identification and Elucidation of Mechanism of Action of ARKILs
(2014)
Prostate cancer cells require the transcription factor Androgen Receptor (AR) for their growth and survival. The current standard of care for patients diagnosed with prostate cancer is anti-androgen therapy, which is not ...
Interaction of NRG1-III and laminin 211 signaling within Schwann cells to achieve proper peripheral nerve radial sorting and myelination
(2015)
Proper ensheathment and myelination of axons within the Peripheral Nervous System require Schwann Cell (SC) interaction with both axons and the extracellular matrix (ECM). SCs rely on these signals in order to recognize ...
The energetics of neuromuscular acetylcholine receptor gating
(2012)
Nicotinic neuromuscular acetylcholine receptors (nAChRs) are members of the pentameric ligand-gated ion channel family and function as signal transducers. The driving force for the opening conformational change is a ∼6000 ...
Potential Role of the GLUT4 Tether TUG in AMPK-mediated Glucose Uptake
(2012)
Type 2 diabetes is quickly growing into an epidemic. Often known for its hyperglycemic state, type 2 diabetes also leads to dyslipidemia, β-cell dysfunction, and increased inflammation. These characteristics make the ...
Tissue engineering for cardiovascular regeneration - Stem cells, Biomaterials, and Animal preclinical model
(2012)
This thesis addresses some approach for tissue engineering in cardiovascular regeneration. Cell source, biomaterials, ex vivo and in vivo assessment are all discussed step by step. This dissertation provides a good ...
Identifying candidate genes for a mutation that suppresses neurodegeneration in the Drosophila model of Leigh syndrome
(2012)
Mitochondrial dysfunction is involved in many neurodegenerative diseases in humans. The levy 1 mutation is the first case ever reported of a mutation that occurs in the nuclear encoded structural subunit of COX, leading ...
Genetic determinants of mitochondrial function and dysfunction
(2012)
Maintenance of the mitochondrial genome is essential for respiration and other mitochondrial functions which are ultimately required for stability of the nuclear genome. In this work, I investigated several genetic ...
Design and analysis: Scaling up of bioreactor towards directed differentiation of human embryonic stem cells
(2012)
Embryonic stem cells will be an effective tool as a renewable source in regenerative medicine mainly due to their extensive proliferation and ability to differentiate into various lineages of cells. Widespread use of ...
Further Insights into the Functional Roles of VTF, NPH I, and RNA Secondary Structure in Vaccinia Early Gene Transcription Termination
(2011)
Vaccinia virus is a large (2 um), double-stranded DNA virus. Unlike many other DNA viruses, vaccinia completes its entire life cycle in the host cytoplasm and therefore, encodes for its own machinery for gene expression ...